Dermal fillers

Hyaluronic acid · Juvéderm Volbella, Voluma, Volift and Volux; Restylane Kysse and Lyft

How it works

A gel in the dermis, or below the lip’s lining, that lifts the surface above it

DermisNeedle or cannula

Hyaluronic acid gelSkin lifted above the gel

Layers, top to bottom: epidermis, dermis, subcutaneous tissue, muscle, bone.

EpidermisDermisSubcutaneous tissueMuscleBoneNeedle or cannula

Hyaluronic acid gelSkin lifted above the gel

Lips and folds in the dermis; cheeks, jawline and under the eyes deeper. Where each product’s US directions for use place it: Volbella’s lip lines, Kysse’s perioral lines and Volift’s folds in the dermis, Kysse in the lips below the lining; Voluma, Lyft, Volux and Volbella under the eyes in the subcutaneous tissue or on the bone. Illustrations are schematic.

What it costs

$880 a syringe of Volbella at one clinic

AreaPer 1 mL syringe
Juvéderm Volbella$8801 clinic
Juvéderm Voluma$800 – $9802 clinics
Juvéderm Volift$8801 clinic
Juvéderm Volbella$8801 clinic
Juvéderm Volux$800 – $9802 clinics

The study’s amount at the clinic price

$2,6403 syringes at $880, before tax

2.6 mL is the median that reached optimal correction in Volbella’s pivotal study in the lips and around the mouth, a touch-up included, 168 people.

Twelve clinic pages, five maker studies. Ten pages state a full-syringe price, $550 to $1,000, whichever filler they carry; two name a product. Study amounts are the medians to optimal correction, a touch-up included, in each product’s US directions for use. Canadian dollars before tax, as the clinic pages state them.

Results & duration

Fuller lips for four in five or more at two to three months

One pivotal study per product, run by its maker. Each number is read from the product’s US directions for use, and is that product’s in that area, not the class’s.

Lips · Volbella

Doctor-rated fullness

Fuller lips at three months

80.3%Volbella · 122 of 152 people

70.8%Restylane-L · 34 of 48 people

A point or more on the maker’s scale, rated blind. The study tested that Volbella was no worse than Restylane-L, not better.

Allergan 2021

How long it was measured

Still fuller at one year

61.8%76 of 123 people

The last visit; the end of the effect was not measured.

Allergan 2021

Lips · Restylane Kysse

Doctor-rated fullness

Fuller lips at eight weeks

88%155 of 177 people

A point or more on the maker’s scale, upper and lower lips together, rated blind. The study tested that Kysse was no worse than a control filler the directions do not name, not better.

Galderma 2020

How long it was measured

Still fuller at 48 weeks

60%101 of 169 people

The last visit; the end of the effect was not measured.

Galderma 2020

How long do hyaluronic acid fillers last?

Six months to a year or more, Health Canada says. The maker studies measured longer, and most people were still improved at the last visit: Volbella in the lips and under the eyes at one year, Voluma in the cheeks at two years, Volift in the nasolabial folds at 18 months, Volux along the jawline at one year, Restylane Kysse in the lips at 48 weeks and Lyft in the cheeks at one year by photograph, where 57.4% of the untreated also counted as improved, each the last visit measured, not the end of the effect. The figures above carry the shares.

Health Canada · Cosmetic injections (2015) · Allergan Volbella 2021 §7, Voluma 2013 §7, Vollure 2023 §7, Volux 2023 §7 · Galderma Kysse 2020 §7, Lyft 2018 MA-1400-05

Recovery & risks

Swelling for most, 30 days or less

Juvéderm Volbella

Volbella in the lips · 30-day diaries, 154 people

  • Swelling92.9%
  • Tenderness89.6%
  • Firmness89%
  • Bruising89%
Most reactions
Mild or moderate; 30 days or less.
Weeks later
Lasting past 30 days, counted as adverse events, in 84 of 168 people, mostly a lump at the injection site; 7 had lumps or swelling appear weeks to months after; all resolved.
Rated severe
40% of the 150 with a response, and 48% of the 50 on Restylane-L, the control: “incapacitating with inability to work or do usual activity”, the study’s own scale; the directions report no significant difference between the two.

Restylane Kysse

Kysse in the lips · 30-day diaries, 183 people

  • Swelling90.2%
  • Tenderness87.4%
  • Bruising85.8%
  • Lumps84.2%
Most reactions
Mostly “tolerable”, the study’s own scale, and under 2 weeks; any reaction at all ran 15 to 30 days for 49.2% of the 179 with one.
Weeks later
Treatment-related adverse events in 39 of 185 people, most often a mass at the injection site, typically gone within 30 days; 10 had one begin 21 days or more after; all mild or moderate, resolved or stable.
Rated severe
“Disabling” for 3.4% of the 179 with a response, “affects daily activities” for 29.1%, the study’s own scale; the directions report no significant difference from the control.

Side effects reported to Health Canada

A lump in 32.1% of 168 people after Volbella in the lips. Gel in a vessel: no rate established.

A mass at the injection site in 10.3% of 185 people, a nodule in 5.4%, after Kysse in the lips. Gel in a vessel: no rate established.

Lumps and nodules

Skin necrosis, from gel in a vessel

Vision impairment or blindness

Reactions reported to Health Canada, and the directions’ warning on injection into a vessel · Illustrations are schematic.

Read from each product’s US directions for use. The diaries of each product’s pivotal study, 30 days or 14, and the adverse events counted past them. Downtime is not counted in them; the nearest measure is the share who rated a reaction severe, the study’s own scale. The harms on the cards are those reported to Health Canada for dermal fillers.

Frequently asked questions

Licensed as Class III medical devices, product by product; this page reads Allergan’s four and Restylane’s two. Health Canada lists Juvéderm Volbella with Lidocaine on licence 90956, Voluma with Lidocaine on 77899, Volift with Lidocaine on 93534 and Volux on 102650, and under Q-Med, Restylane Kysse on 95283 and Restylane Lyft Lidocaine on the Restylane family licence 1934; other hyaluronic acid fillers sold in Canada hold licences of their own under their makers’ names. A licence records Health Canada’s review of the device against its safety and effectiveness requirements for the use filed; it does not establish every benefit, area or duration a clinic advertises.Health Canada · MDALL licences 90956, 77899, 93534, 102650, 95283 and 1934

GST or HST applies to taxable cosmetic treatments: 13% in Ontario, 5% where only GST is charged. The clinic prices here are before tax. A treatment for a medical or reconstructive purpose may be exempt when it meets the applicable health-care exemption’s conditions, including who supplies or performs the service; its purpose alone does not establish an exemption.Excise Tax Act · s. 165, Sch. V Pt. II ss. 1, 1.1, 1.2 and 5 to 7, Sch. VIII

A physician, a nurse practitioner, or a nurse working under one. The College of Nurses of Ontario’s guideline on aesthetic services (2026) states that injecting neuromodulators and dermal fillers involves two controlled acts, so an RN or RPN needs an order or directive from a nurse practitioner or physician, while nurse practitioners are autonomous. Under the College of Physicians and Surgeons of Ontario’s delegation policy, a physician who delegates remains accountable. Other provinces set their own rules.CNO · Aesthetic services, practice guideline (2026) · CPSO · Delegation of controlled acts

Not in the figures above. Every number is read from the product’s own pivotal study, run by its maker, Allergan or Galderma, for its US approval and reported in the directions for use the FDA reviewed. The raters were blind to treatment and each study had a comparison, but the maker chose the scale, ran the study and wrote it up. This page cites no trial run by anyone else.Allergan Volbella 2021 §7, Voluma 2013 §7, Vollure 2023 §7, Volux 2023 §7 · Galderma Kysse 2020 §7, Lyft 2018 MA-1400-05

Yes, with hyaluronidase, an enzyme that breaks down hyaluronic acid. The Juvéderm directions list hyaluronidase injection among the treatments when gel blocks a vessel; Kysse’s list it among the treatments reported for such events. No hyaluronidase product holds a Canadian drug identification number on its own; a 2021 survey of Canadian plastic surgeons reports it obtained through Health Canada’s Special Access Program or compounded by a pharmacy. The enzyme has side effects of its own. Two US hyaluronidase labels, which list no filler use among their indications, report injection-site reactions, such as redness and pain, most often and allergic reactions in under 0.1% of people, rarely anaphylactic-like, and rule it out for anyone hypersensitive to it. Whether to dissolve, and when, is the injector’s assessment.Allergan Volbella 2021 instruction 18, Voluma 2013 instruction 13 · Galderma Kysse 2020 §6.B · Olaiya 2021, PMID 35990397 · Health Canada · DPD · Hylenex recombinant 2024 and Amphadase 2024 US labels §§ 1, 4 and 6

Sources