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Dermal fillers
Hyaluronic acid · Juvéderm Volbella, Voluma, Volift and Volux; Restylane Kysse and Lyft
How it works
A gel in the dermis, or below the lip’s lining, that lifts the surface above it
Hyaluronic acid gelSkin lifted above the gel
Layers, top to bottom: epidermis, dermis, subcutaneous tissue, muscle, bone.
Hyaluronic acid gelSkin lifted above the gel
What it costs
$880 a syringe of Volbella at one clinic
| Area | Per 1 mL syringe |
|---|---|
| Juvéderm Volbella | $8801 clinic |
| Juvéderm Voluma | $800 – $9802 clinics |
| Juvéderm Volift | $8801 clinic |
| Juvéderm Volbella | $8801 clinic |
| Juvéderm Volux | $800 – $9802 clinics |
The study’s amount at the clinic price
$2,6403 syringes at $880, before tax
2.6 mL is the median that reached optimal correction in Volbella’s pivotal study in the lips and around the mouth, a touch-up included, 168 people.
Results & duration
Fuller lips for four in five or more at two to three months
Lips · Volbella
Doctor-rated fullness
Fuller lips at three months
80.3%Volbella · 122 of 152 people
A point or more on the maker’s scale, rated blind. The study tested that Volbella was no worse than Restylane-L, not better.
How long it was measured
Still fuller at one year
61.8%76 of 123 people
The last visit; the end of the effect was not measured.
Lips · Restylane Kysse
Doctor-rated fullness
Fuller lips at eight weeks
88%155 of 177 people
A point or more on the maker’s scale, upper and lower lips together, rated blind. The study tested that Kysse was no worse than a control filler the directions do not name, not better.
How long it was measured
Still fuller at 48 weeks
60%101 of 169 people
The last visit; the end of the effect was not measured.
How long do hyaluronic acid fillers last?
Six months to a year or more, Health Canada says. The maker studies measured longer, and most people were still improved at the last visit: Volbella in the lips and under the eyes at one year, Voluma in the cheeks at two years, Volift in the nasolabial folds at 18 months, Volux along the jawline at one year, Restylane Kysse in the lips at 48 weeks and Lyft in the cheeks at one year by photograph, where 57.4% of the untreated also counted as improved, each the last visit measured, not the end of the effect. The figures above carry the shares.
Health Canada · Cosmetic injections (2015) · Allergan Volbella 2021 §7, Voluma 2013 §7, Vollure 2023 §7, Volux 2023 §7 · Galderma Kysse 2020 §7, Lyft 2018 MA-1400-05
Recovery & risks
Swelling for most, 30 days or less
Juvéderm Volbella
Volbella in the lips · 30-day diaries, 154 people
- Swelling92.9%
- Tenderness89.6%
- Firmness89%
- Bruising89%
- Most reactions
- Mild or moderate; 30 days or less.
- Weeks later
- Lasting past 30 days, counted as adverse events, in 84 of 168 people, mostly a lump at the injection site; 7 had lumps or swelling appear weeks to months after; all resolved.
- Rated severe
- 40% of the 150 with a response, and 48% of the 50 on Restylane-L, the control: “incapacitating with inability to work or do usual activity”, the study’s own scale; the directions report no significant difference between the two.
Restylane Kysse
Kysse in the lips · 30-day diaries, 183 people
- Swelling90.2%
- Tenderness87.4%
- Bruising85.8%
- Lumps84.2%
- Most reactions
- Mostly “tolerable”, the study’s own scale, and under 2 weeks; any reaction at all ran 15 to 30 days for 49.2% of the 179 with one.
- Weeks later
- Treatment-related adverse events in 39 of 185 people, most often a mass at the injection site, typically gone within 30 days; 10 had one begin 21 days or more after; all mild or moderate, resolved or stable.
- Rated severe
- “Disabling” for 3.4% of the 179 with a response, “affects daily activities” for 29.1%, the study’s own scale; the directions report no significant difference from the control.
Side effects reported to Health Canada
A lump in 32.1% of 168 people after Volbella in the lips. Gel in a vessel: no rate established.
A mass at the injection site in 10.3% of 185 people, a nodule in 5.4%, after Kysse in the lips. Gel in a vessel: no rate established.
Lumps and nodules
Skin necrosis, from gel in a vessel
Vision impairment or blindness
Reactions reported to Health Canada, and the directions’ warning on injection into a vessel · Illustrations are schematic.
Frequently asked questions
Sources
- Health Canada · Cosmetic injections (2015)
- Health Canada · MDALL licences 90956, 77899, 93534 and 102650
- Allergan · Volbella US directions
- Allergan · Voluma US directions
- Allergan · Vollure XC (Volift) US directions
- Allergan · Volux US directions
- Health Canada · MDALL, Q-Med licences 95283 and 1934
- Galderma · Restylane Kysse US directions
- Galderma · Restylane Lyft with Lidocaine US directions
- Health Canada · Drug Product Database, hyaluronidase
- Olaiya 2021, PMID 35990397 · Hyaluronidase access among Canadian plastic surgeons
- Halozyme · Hylenex recombinant (hyaluronidase) US prescribing information (2024)
- Amphastar · Amphadase (hyaluronidase) US prescribing information (2024)
- College of Nurses of Ontario · Aesthetic services, practice guideline (2026)
- CPSO · Delegation of controlled acts, policy
- Excise Tax Act · s. 165, Sch. V Pt. II, Sch. VIII