Skin boosters

Hyaluronic acid · Restylane Skinboosters Vital and Teosyal PureSense Redensity 1

How it works

Microdroplets of hyaluronic acid in the dermis, holding water there

DermisNeedle or cannula

Hyaluronic acid microdropletsWater held around each droplet

Layers, top to bottom: epidermis, dermis, subcutaneous tissue, muscle, bone.

EpidermisDermisSubcutaneous tissueMuscleBoneNeedle or cannula

Hyaluronic acid microdropletsWater held around each droplet

In the dermis, as a series of small injections. Restylane Skinboosters Vital, 20 mg/mL: “in the dermal layer of the skin”, for the lower cheek, jawline and backs of the hands its directions name, its effect the water the hyaluronic acid holds. Teosyal Redensity 1, 15 mg/mL, in its European directions: “into the dermis or subcutaneously”, by multipuncture, for the face, neck and neckline. Illustrations are schematic.

What it costs

$650 a 1 mL syringe at one clinic, 2 mL a session in the study

AreaPer 1 mL syringe
Restylane Skinboosters Vital$6501 clinic
Restylane Skinboosters Vital$6501 clinic

One session at the study’s volume

$1,3002 syringes at $650, before tax; not the full course

2 mL a session, diluted with saline and lidocaine and spread across the whole face in about 100 points, is what an independent Korean study injected in each of three sessions 4 weeks apart, 30 women. The maker’s own face trial states no volume.

Twelve clinic pages, five with a price. Two price the 1 mL syringe, one naming Restylane Skinboosters at $650, one Redensity 1 at $500 and $1,200 for its 3 mL syringe. Two price the session with no volume, $400 to $700, one of them selling three sessions for $1,593; one prices a microneedling delivery by the area. Study amounts are each study’s volume a session; the directions recommend three sessions. Canadian dollars before tax, as the clinic pages state them.

Results & duration

Self-rated improvement in the maker’s face trial

Two trials, both the maker’s, one an unpublished registry record. The face trial compared two sessions with three and had no untreated group; the hand trial left each person’s other hand untreated and rated it blind.

Self-rated, three sessions

Improved at three months

79.2%Three sessions · 19 of 24 people

72%Two sessions · 18 of 25 people

Improved, much improved or very much improved on the Global Aesthetic Improvement Scale, in the person’s own rating; the investigators, not blind, rated 95.8% of the three-session group improved. No untreated group. Results posted to the registry; no paper.

Galderma, NCT02403986 results

How long it was measured

Still improved at 18 months

81%Three sessions · 17 of 21 people

77.3%Two sessions · 17 of 22 people

The last visit, of those still followed, in their own rating; the investigators rated every one of the 21 improved. The end of the effect was not measured.

Galderma, NCT02403986 results

How long do skin boosters last?

The directions plan on months, not years. Restylane’s report improvement up to 6 months after the initial treatment in the maker’s clinical studies and recommend a maintenance treatment about every 6 months; Teoxane’s give Redensity 1 an estimated lifetime of at least 3 months and advise a session two to three times a year. The trials measured longer: 81% of the three-session group still rated themselves improved at 18 months in the maker’s face trial, and 87% of treated hands were still rated improved at 15 months in its hand trial, each the last visit measured, not the end of the effect. Health Canada puts dermal fillers generally at six months to a year or more.

Restylane Skinboosters directions · Redensity 1 directions · Galderma, NCT02403986 results · Wu 2020, PMID 31769596 · Health Canada · Cosmetic injections (2015)

Recovery & risks

Bruising, redness and swelling usually last days

The maker’s face trial · 53 women, 18 months

Most reactions
Bruising, redness, itching, swelling, pain or tenderness at the site, resolving on their own within a few days, the directions state. After marketing, one report of redness, inflammation, pain, a papule or nodule, or swelling per 10,000 to 50,000 treatments; of bruising or a hard area per 50,000 to 100,000.
During follow-up
Over 18 months: swelling at the site in 4 of 53, a nodule in 2, pain in 2; one serious swelling of the face, in the three-session group. The record keeps no diaries.
Next session
Three treatments 4 weeks apart, the directions recommend, then a maintenance treatment about every 6 months; at most 5 mL a session and at most 20 mL a year.

Side effects reported to Health Canada

A lump: a nodule in 2 of 53 in the trial; in rare cases an intradermal lump has remained for several months, very rarely longer than a year, the directions state. Gel in a vessel: no rate established.

Lumps and nodules

Skin necrosis, from gel in a vessel

Pigmentation changes in darker skin

Reactions reported to Health Canada for dermal fillers, and the directions’ warnings on injection into a vessel and on skin types IV to VI · Illustrations are schematic.

Read from the trials and the directions for use. The face trial’s registry record counts adverse events over 18 months and keeps no diaries; the hand trial’s diaries are summarized in its paper, not tabulated. Downtime is not counted in either; the nearest measure is the days the diaries’ reactions took to resolve. The harms on the cards are those reported to Health Canada for dermal fillers, and the pigmentation changes the Restylane directions report in skin types IV to VI.

Frequently asked questions

Licensed as Class III medical devices, product by product. Health Canada lists Restylane Skinboosters Vital Lidocaine and Vital Light Lidocaine on Q-Med’s licence 97960, first issued in 2016, and Teosyal PureSense Redensity 1, listed as Redensity I, in 1 mL and 3 mL syringes, on Teoxane’s licence 69640 among the Teosyal family. A licence records Health Canada’s review of the device against its safety and effectiveness requirements for the use filed; it does not establish every benefit, area or duration a clinic advertises.Health Canada · MDALL licences 97960 and 69640

GST or HST applies to taxable cosmetic treatments: 13% in Ontario, 5% where only GST is charged. The clinic prices here are before tax. A treatment for a medical or reconstructive purpose may be exempt when it meets the applicable health-care exemption’s conditions, including who supplies or performs the service; its purpose alone does not establish an exemption.Excise Tax Act · s. 165, Sch. V Pt. II ss. 1, 1.1, 1.2 and 5 to 7, Sch. VIII

A physician, a nurse practitioner, or a nurse working under one. The College of Nurses of Ontario’s guideline on aesthetic services (2026) names administering a substance by injection among the controlled acts, so an RN or RPN needs an order or directive from a nurse practitioner or physician, while nurse practitioners are autonomous. Both makers’ directions restrict the product to trained health care practitioners who know the anatomy of the site. Other provinces set their own rules.CNO · Aesthetic services, practice guideline (2026) · Restylane Skinboosters and Redensity 1 directions

Not the results above. Both trials in the figure are Galderma’s: the face trial is Galderma’s, its results existing only as a registry record, and the hand trial was run by Galderma at three hospitals in China, with a blinded evaluator and an untreated hand as the control. The only independent study on the page, from a Korean plastic surgery department, supplies the 2 mL a session in the cost figure; it had 30 women, no comparison group, and reported 77% satisfied. The prospective SKINQARE study, funded by Teoxane, assessed Redensity 1 after RHA1; its results do not describe Redensity 1 used alone.Galderma, NCT02403986 results · Wu 2020, PMID 31769596 · Lee 2015, PMID 26015882 · Rosso 2025, PMID 40509910

Three, then maintenance. Restylane’s directions recommend three treatments 4 weeks apart and a maintenance treatment about every 6 months, at most 5 mL a session and at most 20 mL a year; Teoxane’s advise two to three sessions 3 or 4 weeks apart for Redensity 1, then two to three a year, at most 6 mL a session. The maker’s face trial randomized women to two or three initial sessions and found the three-session group ahead at every visit in their own rating, 79.2% against 72% improved at three months.Restylane Skinboosters directions · Redensity 1 directions · Galderma, NCT02403986 results

Sources

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Aesthetic procedures in Canada and the products they use, source by source

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